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Updated: Jun 14, 2025

Purification of High Yield Extracellular Vesicle Preparations Away from Virus
Published on: September 12, 2019
Localized Virtual Purification
Hideaki Hakoshima1,2, Suguru Endo3,4, Kaoru Yamamoto3
1Graduate School of Engineering Science, <a href="https://ror.org/035t8zc32">Osaka University</a>, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
Abstract:
Analog and digital quantum simulators can efficiently simulate quantum many-body systems that appear in natural phenomena. However, experimental limitations of near-term devices still make it challenging to perform the entire process of quantum simulation. The purification-based quantum simulation methods can alleviate the limitations in experiments such as the cooling temperature and noise from the environment, while this method has the drawback that it requires global entangled measurement with a prohibitively large number of measurements that scales exponentially with the system size. In this Letter, we propose that we can overcome these problems by restricting the entangled measurements to the vicinity of the local observables to be measured, when the locality of the system can be exploited. We provide theoretical guarantees that the global purification operation can be replaced with local operations under some conditions, in particular for the task of cooling and error mitigation. We furthermore give a numerical verification that the localized purification is valid even when conditions are not satisfied. Our method bridges the fundamental concept of locality with quantum simulators, and therefore is expected to open a path to unexplored quantum many-body phenomena.
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