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Published on: January 28, 2019
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Neuronal AMPK regulates lipid transport to microglia
Ju-Young Bae1, Julie Jacquemyn2, Maria S Ioannou3
1Department of Physiology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Trends in Cell Biology
|September 6, 2024
Abstract
None:
In neurodegeneration, neurons release lipids that accumulate in glial lipid droplets (LDs). But what controls lipid transport and how does this affect glia? A recent study by Li et al. discovered that the loss of neuronal AMP-activated protein kinase (AMPK) activity promotes lipid efflux, which drives a proinflammatory state in microglia.

