Association between muscle mass and overall survival among colorectal cancer patients at tertiary cancer center in the Middle East
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View abstract on PubMed
Summary
This summary is machine-generated.Higher muscle mass (MM) is linked to better survival for colorectal cancer (CRC) patients. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) showed no significant impact on overall survival (OS).
Area Of Science
- Oncology
- Radiology
- Nutritional Science
Background
- Pre-treatment low muscle mass is increasingly recognized as a predictor of poor outcomes in cancer patients.
- The prognostic value of body composition, including adipose tissue and muscle mass, in colorectal cancer (CRC) requires further investigation.
Purpose Of The Study
- To investigate the correlation between Visceral Adipose Tissue (VAT), Subcutaneous Adipose Tissue (SAT), and Muscle Mass (MM) measured by CT scans, and overall survival (OS) in colorectal cancer (CRC) patients.
- To identify potential prognostic factors influencing OS in CRC.
Main Methods
- Retrospective review of medical records and CT scans from 408 CRC patients diagnosed between 2007 and 2018.
- Measurement of VAT, SAT, and MM using Image-J software.
- Survival analysis using Kaplan-Meier curves and multivariate Cox regression.
Main Results
- Higher muscle mass (MM) was significantly associated with an improved 5-year overall survival (OS) rate.
- No significant difference in OS rates was observed based on SAT or VAT.
- Age, cancer stage, grade, and surgical intervention were also identified as significant prognostic factors for OS.
Conclusions
- Higher muscle mass is a favorable prognostic indicator for overall survival in colorectal cancer patients.
- Body composition, specifically muscle mass, may be a modifiable factor influencing CRC patient outcomes.
- Findings support the potential benefit of exercise and nutritional interventions to improve outcomes for CRC patients.
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