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Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Repeatedly experiencing the McGurk effect induces long-lasting changes in auditory speech perception.

John F Magnotti1, Anastasia Lado1, Yue Zhang2

  • 1Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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Repeatedly experiencing the McGurk effect for 14 days changes auditory speech perception. This fusion-induced recalibration (FIR) makes auditory speech alone evoke the fused percept, persisting long-term.

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Area of Science:

  • Cognitive Science
  • Neuroscience
  • Speech Perception

Background:

  • The McGurk effect demonstrates audiovisual speech integration, where conflicting auditory and visual cues create a novel percept.
  • Understanding the plasticity of speech perception is crucial for language acquisition and processing.

Purpose of the Study:

  • To investigate whether repeated exposure to the McGurk effect can induce lasting changes in auditory-only speech perception.
  • To characterize the nature and persistence of this induced perceptual change.

Main Methods:

  • Participants experienced the McGurk effect daily for 14 days.
  • Auditory-only speech perception was assessed before, during, and after the exposure period.
  • A causal inference model was used to predict individual differences in recalibration.

Main Results:

  • Repeated McGurk effect exposure led to fusion-induced recalibration (FIR), where auditory stimuli alone evoked the fused percept.
  • FIR was talker- and syllable-specific and persisted for over a year in some participants.
  • FIR was absent in participants who did not experience the McGurk effect, indicating it was driven by multisensory prediction error.

Conclusions:

  • The study demonstrates that multisensory experiences can induce persistent, long-lasting changes in auditory speech perception.
  • Fusion-induced recalibration highlights the dynamic nature of speech perception and its susceptibility to audiovisual integration.
  • These findings have implications for understanding neural plasticity in language networks and potential applications in language learning interventions.