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Rosette-forming multicentric B-cell lymphoma in a giant panda
Anne C N Tse1, Christopher J Brackman1, Carlton P M Yuen1
1Tai Lung Veterinary Laboratory, Agriculture, Fisheries and Conservation Department, Government of Hong Kong SAR, Hong Kong SAR, China.
Summary
A rare B-cell lymphoma was diagnosed in a giant panda with prolonged anorexia and vomiting. This study details the clinical signs, gross, microscopic, and immunohistochemistry findings of this unusual neoplastic disease.
Area of Science:
- Veterinary Pathology
- Oncology
- Comparative Medicine
Background:
- Limited literature exists on non-infectious diseases in giant pandas, with most available data in Chinese.
- Previous studies on giant panda diseases primarily focus on infectious agents.
- Understanding neoplastic diseases is crucial for the health management of this vulnerable species.
Observation:
- A 35-year-old captive male giant panda presented with anorexia and vomiting.
- Postmortem examination revealed generalized lymphadenopathy, splenomegaly, hepatomegaly, ascites, and thickened gallbladder mucosa.
- Histological analysis identified a densely cellular neoplasm composed of CD79a-positive B lymphocytes.
Findings:
- The neoplasm effaced the normal architecture of multiple organs.
- Neoplastic B lymphocytes exhibited features resembling Homer Wright rosettes, a pattern not previously reported in animal lymphomas.
- Immunohistochemistry confirmed the B-cell origin of the neoplastic lymphocytes.
Implications:
- This case report expands the known spectrum of neoplastic diseases in giant pandas.
- The identification of a novel rosette-forming lymphoma pattern in this species warrants further investigation.
- Findings contribute to the understanding of comparative oncology and disease management in zoological settings.
