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Updated: Jun 14, 2025

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RNA splicing factor RBFOX2 is a key factor in the progression of cancer and cardiomyopathy

Jinze Shen1, Jianqiao Shentu1, Chenming Zhong2

  • 1Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, China.

Clinical and Translational Medicine
|September 7, 2024
PubMed
Abstract

Insights

RNA-binding fox-1 homologue 2 (RBFOX2) is a key regulator of alternative splicing, impacting cell differentiation and development. Dysregulation of RBFOX2 is linked to diseases, but structural and drug-targeting research gaps remain.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Alternative splicing of pre-mRNA is crucial for proteome diversity in eukaryotes.
  • RNA-binding fox-1 homologue 2 (RBFOX2) is a critical splicing regulator influencing cellular processes.
  • RBFOX2 controls alternative splicing of numerous transcripts, impacting differentiation and development.

Purpose of the Study:

  • To provide a comprehensive analysis of RBFOX2 and its splicing activity.
  • To elucidate RBFOX2's direct and indirect binding mechanisms in pre-mRNA splicing.
  • To identify research gaps and limitations in current RBFOX2 studies.

Main Methods:

  • Literature review and critical assessment of existing research on RBFOX2.
  • Analysis of RBFOX2's role in alternative splicing mechanisms.
  • Identification of challenges in structural characterization and therapeutic development.

Main Results:

  • RBFOX2 significantly influences alternative splicing, affecting vital cellular functions.
  • Dysregulation of RBFOX2-mediated splicing is associated with cardiovascular diseases and cancers.
  • Key challenges include incomplete structural characterization and a lack of RBFOX2-targeting drugs.

Conclusions:

  • Existing knowledge on RBFOX2 is assessed, highlighting research gaps.
  • Strategic insights are provided for future studies to bridge identified limitations.
  • Addressing these challenges is crucial for unlocking RBFOX2's therapeutic potential in various diseases.
Keywords:
RBFOX2alternative splicingpre‐mRNAtherapeutic targeting

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