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Related Experiment Videos

Development of new renal scars: a collaborative study.

J M Smellie, P G Ransley, I C Normand

    British Medical Journal (Clinical Research Ed.)
    |June 29, 1985
    PubMed
    Summary
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    Early diagnosis and prompt treatment are crucial for preventing kidney scarring in children with urinary tract infections. Even children over age 5 remain vulnerable to developing new renal scars.

    Area of Science:

    • Pediatrics
    • Nephrology
    • Radiology

    Background:

    • Renal scarring in children can result from urinary tract infections (UTIs).
    • Factors influencing the development of new renal scars require further investigation.
    • Understanding these factors is essential for effective prevention and management strategies.

    Purpose of the Study:

    • To analyze clinical data and serial radiographs of infants and children to identify factors contributing to renal scar development.
    • To assess the incidence and extent of new renal scarring in a pediatric cohort.
    • To evaluate the impact of delayed diagnosis, recurrent infections, and vesicoureteric reflux on renal scar formation.

    Main Methods:

    • Retrospective analysis of clinical data and serial radiographs from 74 children (66 girls, 8 boys) without duplex kidney or obstruction.

    Related Experiment Videos

  • Radiological assessment for the development of new renal scars.
  • Correlation of scarring with factors such as age at scarring, history of urinary infection, vesicoureteric reflux, and management delays.

    • Main Results:

    • New renal scars developed in 87 kidneys (74 previously normal, 13 previously scarred); extensive scarring occurred in 16 kidneys.
    • Urinary infection was present in all children; diagnosis and treatment were delayed in 45, and 58 experienced recurrent infections.
    • Vesicoureteric reflux was observed in 67 children, and social problems impacted management in 22.
    • Thirty-four children were aged 5 or older when scarring occurred.

    Conclusions:

    • Early diagnosis, prompt and effective treatment, thorough investigation, and long-term supervision are critical for reducing renal scarring in children with UTIs.
    • Children over the age of 5 remain susceptible to developing renal scars.
    • Inadequate management, including delayed diagnosis and insufficient prophylaxis, contributes significantly to renal scar progression.