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Updated: Jul 26, 2026

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
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Salidroside prevents cadmium chloride-induced DNA damage in human fetal lung fibroblasts

Yufei Wu1, Chuan Sun2

  • 1Anglo-Chinese School (International), Singapore.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|September 7, 2024
PubMed
Abstract

Insights

Salidroside (SAL) effectively protects human cells from cadmium-induced DNA damage. This study shows SAL’s potential in preventing genotoxicity, though its mechanism needs more research.

Area of Science:

  • Environmental toxicology
  • Pharmacology
  • Cell biology

Background:

  • Cadmium (Cd) is a genotoxic environmental pollutant linked to cancer.
  • Preventing cadmium-induced genotoxicity is critical but under-researched.
  • Salidroside (SAL), from Rhodiola rosea L., has potential health benefits.

Purpose of the Study:

  • To investigate the therapeutic effect of Salidroside (SAL) on cadmium (Cd)-induced genotoxicity.
  • To evaluate SAL's protective role against DNA damage caused by Cd exposure.

Main Methods:

  • Human fetal lung fibroblasts were exposed to CdCl2.
  • DNA damage was assessed using γH2AX expression and the alkaline comet assay.
  • Intracellular reactive oxygen species (ROS) levels were measured.

Main Results:

  • Cadmium exposure caused significant DNA damage in fibroblasts.
  • Salidroside treatment notably attenuated the Cd-induced DNA damage.
  • SAL did not reduce intracellular ROS levels in Cd-exposed cells.

Conclusions:

  • Salidroside effectively prevents cadmium-induced DNA damage in human fetal lung fibroblasts.
  • The precise mechanism by which SAL protects against Cd genotoxicity requires further investigation.
Keywords:
CadmiumDNA damageGenotoxicityNatural extractSalidroside

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