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Published on: October 20, 2010
Fluorescence Visualization-Guided Surgery Improves Local Control for Mandibular Squamous Cell Carcinoma
Takamichi Morikawa1, Takahiko Shibahara2, Masayuki Takano3
1Clinical Fellow, Oral and Maxillofacial Surgery, Mistuwadai General Hospital, Chiba-City, Chiba, Japan; Senior Assistant Professor, Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo, Japan.
Fluorescence visualization-guided surgery (FVS) significantly improved local control (LC) for early-stage mandibular squamous cell carcinoma (MSCC). FVS achieved 94.4% LC compared to 77.2% with conventional surgery, reducing recurrence rates.
Area of Science:
- Oncology
- Surgical Innovation
- Oral Medicine
Background:
- Local recurrence is a significant challenge in mandibular squamous cell carcinoma (MSCC).
- Fluorescence visualization (FV) offers a noninvasive method to detect precancerous lesions around MSCC.
- FV has the potential to decrease local recurrence rates in MSCC patients.
Purpose of the Study:
- To compare local control (LC) rates between fluorescence visualization-guided surgery (FVS) and conventional surgery.
- To evaluate the efficacy of FVS in reducing local recurrence for early-stage (Stages I and II) MSCC.
Main Methods:
- A retrospective cohort study analyzed medical records of MSCC patients from 2000 to 2021.
- Patients with early-stage MSCC who underwent either conventional surgery or FVS were included.
- Local control was defined as no recurrence within 20 mm of the surgical site over 5 years.
Main Results:
- The study included 56 patients (mean age 68.5 years, 58.9% female).
- Five-year local control was significantly higher with FVS (94.4%) compared to conventional surgery (77.2%) (P=0.04).
- Multivariate analysis confirmed FVS as a significant independent predictor of improved LC (P=0.004).
Conclusions:
- Fluorescence visualization-guided surgery demonstrates superior local control for early-stage MSCC.
- FVS is associated with a substantial reduction in local recurrence rates compared to conventional surgical approaches.
- This technique holds promise for improving outcomes in patients with mandibular squamous cell carcinoma.
