Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.The Fat Mass and Obesity-Associated gene (FTO) rs17817449 polymorphism is linked to increased COVID-19 mortality risk. GG homozygotes showed a 2.01-fold higher risk of death from COVID-19 in elderly Caucasians.
Area Of Science
- Genetics and Genomics
- Infectious Diseases
- Epidemiology
Background
- The COVID-19 pandemic has caused significant global mortality.
- The Fat Mass and Obesity-Associated gene (FTO) plays a role in RNA methylation.
- Viral nucleic acid methylation can influence viral viability, making FTO a potential factor in COVID-19 outcomes.
Purpose Of The Study
- To investigate the association between the FTO gene rs17817449 polymorphism and COVID-19 mortality.
- To determine if FTO variability influences the risk of death from COVID-19 in an elderly population.
Main Methods
- A population-based cohort of 5233 elderly subjects (aged 63-87 years) was analyzed.
- COVID-19 mortality data and mortality from other causes were recorded during the pandemic.
- Genotyping for the FTO rs17817449 polymorphism was performed.
Main Results
- The GG homozygote genotype frequency was significantly higher in individuals who died from COVID-19 (34%) compared to survivors (19%) or those who died from other causes (20%).
- After adjusting for confounding factors, GG homozygotes had a 2.01-fold increased risk of death from COVID-19 (OR = 2.01, 95% CI: 1.19-3.41).
- No association was found between FTO polymorphism and mortality from causes other than COVID-19.
Conclusions
- FTO gene variability, specifically the rs17817449 polymorphism, is a significant predictor of COVID-19 mortality.
- This genetic factor appears to specifically impact COVID-19-related deaths in Caucasian populations.
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