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Effect of body position during weaning from total liquid ventilation in piglets
Alexandru Panaitescu1, Christophe Morin1, Mouhamed Amin Boudaouara2
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12e Avenue N, Sherbrooke, Québec J1H 5N4, Canada.
Objective:
To determine if change in body position improves oxygen requirements and respiratory mechanics during the transition from total liquid ventilation (TLV) to gas ventilation.
Methods:
Fourteen piglets underwent TLV, followed by a 2-hour weaning period under conventional gas ventilation. Subjects were randomized to the experimental group (Rotating - R), that was in prone position between the 10th and 30th minute of weaning, or to the static control group (Supine - S).
Results:
Oxygenation index was lower in the R group at 30 minutes in prone position than that in the S group (1.9 [1.6; 2.8] vs 3.5 [3.1; 5.1], p = 0.001). This difference disappeared when subjects resumed the supine position (4.2 [3.8; 4.7] and 4.7 [3.8; 5.4], p = 0.4, for the R and S groups, respectively). The change in body position did not affect respiratory system compliance or inspiratory capacity.
Conclusion:
Prone position improved oxygenation during weaning from TLV. The effect disappeared once piglets returned to the supine position.
