Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Endocrine System

The Endocrine System

The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...

Menopause

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...

Diabetes: Symptoms, Diagnosis, and Complications

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...

Signs of Puberty

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...

Insulin: Dosing Regimen and Adverse Effects

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

BASHH best practice statement on the management of testosterone-associated vulvovaginitis.

International journal of STD & AIDS·2026

Same author

Microbubble Shell Stiffness Engineering Enhances Ultrasound Imaging, Drug Delivery, and Sonoporation.

Advanced materials (Deerfield Beach, Fla.)·2025

Same author

The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes.

Cardiovascular research·2025

Same author

The biomechanics of wounds at physiologically relevant levels: Understanding skin's stress-shielding effect for the quantitative assessment of healing.

Materials today. Bio·2024

Same author

The developmental basis of fingerprint pattern formation and variation.

Cell·2023

Same author

Dynamically Modulated Core-Shell Microfibers to Study the Effect of Depth Sensing of Matrix Stiffness on Stem Cell Fate.

ACS applied materials & interfaces·2021

Search research articles

Related Experiment Video

Updated: Jun 14, 2025

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

Clinical considerations and endocrinological implications in the detransition process.

Laura Charlton¹, Ruth Bond²

¹Gender Identity Service, Management Suite, The Newsam Centre, Seacroft Hospital, York Road, Leeds LS14 6UH, United Kingdom.

Best Practice & Research. Clinical Endocrinology & Metabolism

|September 7, 2024

Summary

Detransition involves reverting to one's gender assigned at birth and presents unique healthcare challenges. Comprehensive patient-centered care, including ethical, psychological, and medical support, is crucial for individuals undergoing detransition.

Keywords:

detransition gender dysphoria gender incongruence hair management hormone management psychosocial needs retransition surgical revisions

More Related Videos

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids

Published on: August 16, 2024

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

Related Experiment Videos

Last Updated: Jun 14, 2025

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids

Published on: August 16, 2024

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

Area of Science:

Medical Ethics
Psychology
Endocrinology
Surgical Science

Background:

Detransition, the process of reverting to one's gender assigned at birth or altering transition goals, poses significant clinical challenges.
Existing healthcare frameworks may not adequately address the multifaceted needs of individuals seeking to detransition.

Purpose of the Study:

To introduce the clinical issue of detransition.
To provide a comprehensive overview of ethical, psychological, legal, surgical, and endocrinological considerations in detransition care.
To emphasize the need for patient-centered care, informed consent, and further research.

Main Methods:

Literature review and synthesis of existing clinical knowledge.
Identification of key ethical, psychological, legal, surgical, and endocrinological factors.
Discussion of psychotherapeutic interventions and support systems.

Main Results:

Detransition requires careful consideration of endocrine management, surgical reversals, and psychological support.
Trauma-focused Cognitive Behavioural Therapy (CBT), Eye Movement Desensitization and Reprocessing (EMDR), and Compassion-Focused Therapy (CFT) are recommended for managing trauma and shame.
Holistic support systems are essential for individuals navigating detransition.

Conclusions:

Healthcare providers must adopt a holistic and patient-centered approach to support individuals undergoing detransition.
Further research is necessary to fully understand and address the specific needs of the detransitioning population.
Integrating ethical, psychological, and medical expertise is vital for effective detransition care.