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A harmonized occupational biomonitoring approach.

Nancy B Hopf1, Christophe Rousselle2, Devika Poddalgoda3

  • 1Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1011 Epalinges-Lausanne, Switzerland.

Environment International
|September 8, 2024
PubMed
Summary
This summary is machine-generated.

Occupational biomonitoring assesses chemical exposures by measuring substances in body fluids, aiding risk assessment. New guidance promotes harmonized biomarker use for evidence-based occupational health management.

Keywords:
Biological monitoringEffect biomarkersExposure biomarkersRisk assessmentRisk managementToxicokinetics

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Area of Science:

  • Occupational Health and Safety
  • Environmental Health
  • Toxicology

Background:

  • Biomonitoring complements chemical risk assessments by measuring chemical concentrations in human body fluids.
  • It accounts for all exposure routes (inhalation, skin absorption, ingestion) and sources.
  • The OECD framework developed guidance for occupational biomonitoring.

Purpose of the Study:

  • To provide practical information for assessing chemical exposures in occupational settings.
  • To establish a stepwise approach for conducting biomonitoring.
  • To promote harmonized application and interpretation of biomarkers for risk management.

Main Methods:

  • Developing a stepwise approach for occupational biomonitoring.
  • Selecting appropriate biomarkers and devising sampling strategies.
  • Establishing procedures for setting up biomonitoring programs using Similar Exposure Group (SEG) approaches.

Main Results:

  • The guidance offers practical information for occupational health professionals, scientists, risk assessors, and regulators.
  • It includes methods for biomarker selection, sampling, laboratory assessment, and result feedback.
  • Proposed Occupational Biomonitoring Levels (OBLs) aid in exposure and risk assessment.

Conclusions:

  • The guidance promotes harmonized application and interpretation of biomarkers.
  • It supports evidence-based occupational risk management measures.
  • Ethical considerations in biomonitoring are also discussed.