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Published on: January 29, 2014
Central auditory system assessment in children and adolescents with cystic fibrosis: electrophysiology and central
Paula Maria Martins-Duarte1, Gabriel Hessel1, Antônio Fernando Ribeiro1
1Centro de Investigação em Pediatria da Faculdade de Ciências Médicas da Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
Insights
Children and adolescents with cystic fibrosis exhibit impaired central auditory processing, including temporal resolution and auditory evoked potentials. This study highlights auditory system differences in CF patients compared to controls.
Area of Science:
- Neuroscience
- Audiology
- Pediatrics
Background:
- Cystic fibrosis (CF) can affect multiple organ systems, including the auditory system.
- Central auditory processing (CAP) is crucial for speech comprehension and sound localization.
- Electrophysiological tests provide objective measures of auditory pathway function.
Purpose of the Study:
- To evaluate the central auditory system in children and adolescents with CF.
- To compare CAP and auditory potentials between CF patients and healthy controls.
- To identify specific auditory processing deficits in CF.
Main Methods:
- A cohort of 117 participants (7-21 years) including 57 with CF and 60 controls underwent CAP behavioral tests and electrophysiological assessments.
- Auditory Brainstem Response (ABR) and Long Latency Auditory Evoked Potential (LLAEP) were recorded.
- Statistical analysis included ANOVA and non-parametric tests (Wilcoxon, Mann-Whitney).
Main Results:
- CF group showed significantly poorer performance on the Gaps-in-Noise (GIN) test, indicating impaired temporal resolution.
- Increased latencies were observed in Auditory Brainstem Response waves I and V, and interpeak intervals I-III and III-V in the CF group.
- Long Latency Auditory Evoked Potential analysis revealed significantly longer P300 latency in the CF group.
Conclusions:
- Children and adolescents with cystic fibrosis demonstrate deficits in central auditory processing, particularly temporal resolution.
- Electrophysiological findings suggest delayed neural transmission in the auditory pathway of CF patients.
- These auditory impairments may impact communication and learning in individuals with cystic fibrosis.
Objective:
This study aims to evaluate the central auditory system of children and adolescents with cystic fibrosis through behavioral assessment of central auditory processing and electrophysiological tests to investigate short and long-latency auditory potentials, comparing them with the results obtained in the control group.
Methods:
117 from 7 to 21 years old patients were evaluated, 57 of them with cystic fibrosis and 60 of the control group, using behavioral evaluation of central auditory processing, auditory brainstem response and long latency auditory evoked potential. The comparison of the research groups was performed using ANOVA for Auditory Brain Response and P300 responses and Wilcoxon and Mann-Whitney tests for Central Auditory Processing responses.
Results:
A statistically significant difference was found in the results of the GIN test between the groups and in the auditory brainstem response latency responses in waves I and V in the comparison between the groups with higher latencies in the study group. A difference was also found between latencies in the interpeak intervals I-III and III-V. The long latency auditory evoked potential analysis shows a statistically significant difference in the latency of the P300 potential, with higher latencies in the study group.
Conclusion:
Cystic fibrosis participants presented worse performance in the gaps-in-noise test compared to the control group in the evaluation of central auditory processing, which indicates impairment of temporal resolution auditory ability. They also showed increased latency in I and V waves of auditory brainstem response, as well as an increase P300 latency in long latency auditory evoked potential.
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