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Updated: Jun 13, 2025

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

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Published on: June 2, 2015

KETAMINE: Neural- and network-level changes.

Vishal Bharmauria¹, Hamidreza Ramezanpour², Afef Ouelhazi³

¹The Tampa Human Neurophysiology Lab & Department of Neurosurgery and Brain Repair, Morsani College of Medicine, 2 Tampa General Circle, University of South Florida, Tampa, FL 33606, USA; Centre for Vision Research and Centre for Integrative and Applied Neuroscience, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada.

|September 8, 2024

Summary

This summary is machine-generated.

Ketamine alters neural tuning and connectivity in the visual cortex by reducing firing variability. This research introduces a dendritic model for understanding ketamine

Keywords:

Hyperconnectivity Ketamine Neural tuning Neuroplasticity Synchrony

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Published on: March 31, 2016

Area of Science:

Neuroscience
Pharmacology
Computational Biology

Background:

Ketamine is a versatile clinical drug with anesthetic, analgesic, and neuropsychiatric applications.
Ketamine influences cognitive functions like memory and induces psychedelic effects.
At the neural level, ketamine modulates firing rates, tuning, oscillations, and network connectivity.

Purpose of the Study:

To review existing literature on ketamine's effects.
To present findings on ketamine's impact on visual cortex neural tuning and connectivity.
To develop a dendritic model of ketamine-induced neural and network changes.

Main Methods:

Literature review.
Experimental studies involving topical ketamine application to the visual cortex.
Synthesis of a dendritic model for neural tuning and network dynamics.

Main Results:

Topical ketamine application to the visual cortex alters neural tuning.
Ketamine promotes enhanced neuronal connectivity by decreasing firing variability.
A novel dendritic model was developed to simulate these network changes.

Conclusions:

The developed model offers potential for targeted cortical network modulation in clinical settings.
Further animal studies are crucial for translating findings and developing combined therapies.
Investigating ketamine's systemic effects deepens understanding of consciousness and aids neuropsychiatric disorder treatment.