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IGF Signaling in the Heart in Health and Disease

Daria A Adasheva1, Daria V Serebryanaya2,3

  • 1Department of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.

Biochemistry. Biokhimiia
|September 8, 2024
PubMed

Insights

The insulin-like growth factor (IGF) system impacts heart health, offering protection but also contributing to disease. Understanding its dual role is key for cardiovascular disease management.

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Molecular Biology

Background:

  • The cardiovascular system is vital for bodily function.
  • Heart physiology relies on a balance between protective and pathological mechanisms.
  • The insulin-like growth factor (IGF) system is crucial for cellular and tissue growth and development.

Purpose of the Study:

  • To review the role of the IGF system in myocardial cardioprotection.
  • To examine the involvement of IGF signaling in cardiovascular disease pathogenesis.
  • To analyze the varying impact of IGF effects in different cardiovascular scenarios.

Main Methods:

  • Literature review of recent data.
  • Analysis of IGF signaling pathways in the myocardium.
  • Synthesis of findings on IGF's dual role in cardiovascular health and disease.

Main Results:

  • The IGF system exhibits both cardioprotective and pathological effects in the myocardium.
  • IGF signaling is implicated in the development of various cardiovascular diseases.
  • The severity of IGF's impact varies depending on the specific cardiovascular context.

Conclusions:

  • The IGF system is a critical regulator in cardiovascular physiology and pathology.
  • Further research into IGF signaling could reveal novel therapeutic targets for cardiovascular diseases.
  • Understanding the context-dependent effects of IGF is essential for effective cardiovascular disease intervention.

Keywords:
IGF-binding proteins (IGFBP)IGFBP-4PAPP-Acardiomyocytescardioprotective effectcardiovascular diseasesinsulin-like growth factors IGF-I and IGF-II

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