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Peering into the mind: unraveling schizophrenia's secrets using models
João V Nani1,2, Alysson R Muotri3, Mirian A F Hayashi4,5
1Department of Pharmacology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil. joao.nani@unifesp.br.
Molecular Psychiatry
|September 8, 2024
Summary
Diverse laboratory models, including cellular, iPSC-derived, and animal models, are crucial for understanding schizophrenia (SCZ) neurobiology. Evaluating these models aids in developing new interventions for this complex mental disorder.
Area of Science:
- Neuroscience
- Psychiatry
- Genetics
Background:
- Schizophrenia (SCZ) is a complex mental disorder with elusive neurobiology.
- Existing research highlights the need for advanced modeling techniques.
Purpose of the Study:
- To provide a comprehensive overview of diverse laboratory modeling approaches for schizophrenia.
- To critically evaluate the strengths and limitations of each model.
Main Methods:
- Review of cellular models (immortalized, iPSC-derived neuronal cultures, brain organoids).
- Analysis of animal models (invertebrate and vertebrate, including genetically engineered models).
- Synthesis of knowledge from diverse modeling techniques.
Main Results:
- Cellular models offer controlled environments for pathway investigation.
- iPSCs and organoids enable patient-specific translational research.
- Animal models recapitulate psychopathological aspects and genetic underpinnings.
Conclusions:
- Integrating findings from various models can build a holistic picture of SCZ pathophysiology.
- This synthesis facilitates new research avenues and informed intervention strategies.
- Diverse models are essential for advancing schizophrenia research and treatment.
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