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Updated: Jun 13, 2025

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Advances on immunotherapy for osteosarcoma.

Shengnan Yu¹, Xudong Yao²

¹Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Molecular Cancer

|September 8, 2024

Summary

This summary is machine-generated.

Osteosarcoma treatment needs breakthroughs, as survival rates remain poor. Immunotherapy shows promise for this bone cancer, with several strategies in clinical development and early research.

Keywords:

Immune microenvironment Immunotherapy Osteosarcoma

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Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Area of Science:

Oncology
Immunology

Background:

Osteosarcoma is a prevalent bone cancer in young individuals with stagnant survival rates.
Existing treatments for metastatic or recurrent osteosarcoma are largely ineffective, necessitating novel therapeutic approaches.

Purpose of the Study:

To review the current landscape of immunotherapies for osteosarcoma.
To explore the role of the tumor microenvironment in osteosarcoma's response to immunotherapy.

Main Methods:

Comprehensive review of preclinical and clinical studies on osteosarcoma immunotherapies.
Analysis of the tumor microenvironment, including tumor-promoting and tumor-suppressing cells.

Main Results:

Immunotherapy has shown efficacy in other solid tumors but faces challenges in osteosarcoma due to its low immunogenicity and immunosuppressive microenvironment.
Several immune-based therapies, including immune checkpoint inhibitors, CAR T-cells, and bispecific antibodies, are under active clinical investigation.
Emerging strategies like modified immune cells, dendritic cell vaccines, and cytokines represent future research directions.

Conclusions:

Despite challenges, immunotherapy holds significant potential for improving osteosarcoma patient outcomes.
Further research into osteosarcoma's tumor microenvironment and novel immunotherapy strategies is crucial for clinical breakthroughs.