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Updated: May 2, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.3K

Evaluation of collateral circulation in patients with internal carotid artery occlusion: A clinical and

Ran Liu1,2,3, Mingjie Gao4, Xinyu Zhao1,2,3

  • 1Department of Vascular Ultrasound, Xuanwu Hospital, Capital Medical University, Beijing, China.

Vascular Medicine (London, England)
|September 9, 2024
PubMed

Insights

Anterior communicating artery collaterals improve cerebral blood flow and reduce stroke severity in internal carotid artery occlusion. Patients with these collaterals show better outcomes.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Cerebrovascular Disease

Background:

  • Internal carotid artery (ICA) occlusion is a primary cause of ischemic stroke.
  • The role of collateral circulation in cerebral hemodynamics during ICA occlusion requires further clarification.
  • This study examines the relationship between collateral vessels and middle cerebral artery (MCA) peak systolic velocity (PSV) in ICA occlusion.

Purpose of the Study:

  • To investigate the correlation between collateral vessels and MCA PSV in patients with ICA occlusion.
  • To assess the impact of specific collateral pathways (anterior communicating artery - ACoA, posterior communicating artery - PCoA, internal-external carotid artery - IECCA) on cerebral hemodynamics.
  • To evaluate the association between collateral status, hemodynamic parameters, and clinical stroke severity.

Main Methods:

  • Recruited 251 patients with unilateral ICA occlusion.
  • Utilized transcranial Doppler imaging to measure MCA PSV and other intracranial arterial velocities.
  • Assessed clinical symptoms using the National Institutes of Health Stroke Scale (NIHSS).

Main Results:

  • Patients with ACoA collaterals exhibited significantly higher MCA PSV and lower NIHSS scores (p < 0.001).
  • Individuals with no significant collaterals or only IECCA had the lowest MCA PSV and highest NIHSS scores.
  • A significant negative correlation was found between MCA PSV and NIHSS scores (r = -0.566, p < 0.001).

Conclusions:

  • Collateral circulation significantly influences cerebral hemodynamics and clinical outcomes in unilateral ICA occlusion.
  • The presence of ACoA collaterals is associated with improved hemodynamic parameters and potentially better clinical outcomes.
  • Findings highlight the importance of collateral status in managing patients with ICA occlusion.
Abstract

Keywords:
cerebrovascular diseasecollateral circulationtranscranial Dopplerultrasonographyvascular imaging/diagnostics

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