Chimeric antigen receptor (CAR) T-cell therapy: an overview for nurses

Area of Science:

• Oncology
• Immunotherapy
• Cellular Therapy

Background:

• Chimeric antigen receptor (CAR) T-cell therapy is an emerging immunotherapy for hematologic malignancies.
• Current UK applications include relapsed/refractory acute lymphoblastic leukemia and diffuse large B-cell lymphoma.
• This therapy presents significant side effects and potential life-threatening toxicities.

Purpose of the Study:

• To provide an overview of CAR T-cell therapy.
• To describe potential side effects and adverse reactions.
• To explore the role of nurses in CAR T-cell therapy and its implications for the nursing workforce.

Main Methods:

• Literature review on CAR T-cell therapy.
• Analysis of potential patient side effects and adverse reactions.
• Discussion of nursing responsibilities and workforce implications.

Main Results:

• CAR T-cell therapy is a complex treatment with notable side effects.
• Nurses are integral to patient support, administration, monitoring, and management of adverse events.
• The expansion of CAR T-cell therapy necessitates workforce adaptation.

Conclusions:

• Nurses are essential in managing CAR T-cell therapy, from decision-making to follow-up care.
• Effective management of side effects and toxicities is critical for patient outcomes.
• The nursing workforce must be prepared for the increasing demand and evolving landscape of CAR T-cell therapy.