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Updated: Jul 20, 2026
Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
Genomic tests for risk stratification in patients with early human epidermal growth factor receptor 2-positive breast
Pier Paolo M Berton Giachetti1,2, Elisa Giordano1,2, Beatrice Taurelli Salimbeni1
1Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS.
Purpose Of Review:
The purpose of this review is to provide a comprehensive overview of human epidermal growth factor receptor 2 (HER2) genomic tests, particularly focusing on the most recent developments and looking at the future prospects of this field, yet to be thoroughly explored.
Recent Findings:
HER2DX is a multifeatured assay, retrospectively proved to add prognostic information and to predict pathological complete response (pCR) in patients with HER2-positive early breast cancer (EBC) undergoing neoadjuvant treatment containing HER2-directed agents. Preliminary data have shown that the assay maintains its predictive capabilities even in the context of chemotherapy-free, anti-HER2 neoadjuvant regimens, potentially selecting patients suitable for treatment de-escalation, having highly HER2-driven malignancies.
Summary:
Multigene prognostic assays have become essential tools in the management of EBC, providing crucial information for risk stratification.
