Growth and plasticity of rat cerebral cortex after central noradrenaline depletion

Male Wistar rats (aged 31 to 33 days) received bilateral intraventricular injections of saline or 6-hydroxydopamine and were subjected to either "standard" or "enriched" rearing conditions for 42 days. The treatment reduced cerebral cortical noradrenaline by 80% and decreased the growth of the cerebral cortex. It did not, however, prevent experience in an enriched environment from enhancing the growth of the cerebral cortex.