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Updated: Jun 13, 2025
07:34
Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
Published on: March 14, 2013
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Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization.
Mu-Rong Chao1,2, Yuan-Jhe Chang1, Marcus S Cooke3
1Department of Occupational Safety and Health, Chung Shan Medical University, Taichung 402, Taiwan.
Trends in Analytical Chemistry : TRAC
|September 9, 2024
Summary
Adductomics studies molecular adducts from exposures. Advances in mass spectrometry improve detection, aiding understanding of environmental health impacts and precision medicine.
Area of Science:
- Biochemistry
- Toxicology
- Molecular Biology
Background:
- Adductomics investigates DNA, RNA, and protein adducts formed by endogenous and exogenous agents.
- These adducts can arise from environmental pollutants, diet, and xenobiotics, affecting cellular function and disease risk, including cancer.
- Understanding adduct formation is crucial for assessing health impacts of exposures.
Purpose of the Study:
- To review advancements in mass spectrometry (MS) for adduct detection.
- To discuss current and emerging trends in adductomics research.
- To highlight the potential of adductomics in environmental health and precision medicine.
Main Methods:
- Review of mass spectrometry (MS) techniques for adductomic analysis.
- Discussion of screening strategies for biomolecular modifications.
- Exploration of methods to differentiate exogenous and endogenous adducts.
Main Results:
- Significant progress in MS instrumentation enhances the detection of diverse adducts, from mono-adducts to complex crosslinks.
- Emerging trends include novel MS applications and multi-omics integration.
- Challenges remain in developing specialized MS spectra databases.
Conclusions:
- Adductomics, powered by MS advancements, offers powerful insights into health effects of environmental exposures.
- The field holds promise for personalized medicine by identifying individual exposure-related risks.
- Further development of databases and integrated approaches will advance adductomics research.
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