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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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  1. Home
  3. A Prognostic Risk Signature Of Two Autophagy-related Genes For Predicting Triple-negative Breast Cancer Outcomes.
  1. Home
  3. A Prognostic Risk Signature Of Two Autophagy-related Genes For Predicting Triple-negative Breast Cancer Outcomes.

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A Prognostic Risk Signature of Two Autophagy-Related Genes for Predicting Triple-Negative Breast Cancer Outcomes.

Bing Yu1, Zhimei Xing2, Xiaoxuan Tian2

  • 1Department of Breast Surgery, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, 300100, People's Republic of China.

Breast Cancer (Dove Medical Press)
|September 9, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Autophagy-related genes EIF4EBP1 and NPAS3 show promise as independent prognostic factors for triple-negative breast cancer (TNBC). This study identified their predictive value for disease progression and survival in TNBC patients.

Keywords:
autophagynomogramprognosisrisk signaturetriple-negative breast cancer

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Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype.
  • Autophagy plays a complex role in TNBC development and progression.

Purpose of the Study:

  • To identify novel autophagy-related genes (ARGs) associated with prognosis in TNBC.
  • To develop a predictive model for TNBC patient outcomes using gene expression data.

Main Methods:

  • Analysis of high-throughput RNA-seq data from 579 TNBC samples (TCGA).
  • Identification of differentially expressed ARGs and prognostic factors using Cox regression and ROC curve analysis.
  • Development of a nomogram integrating gene expression with clinicopathological factors.

Main Results:

  • EIF4EBP1 and NPAS3 expression levels were significantly correlated with prognostic outcomes in TNBC.
  • A predictive model incorporating EIF4EBP1 and NPAS3 accurately estimated 1-, 2-, and 3-year survival rates.
  • Lower NPAS3 expression was observed in TNBC tissues, particularly in Stage III, and influenced drug sensitivity.

Conclusions:

  • The autophagy-related genes EIF4EBP1 and NPAS3 may serve as independent prognostic biomarkers for TNBC.
  • This study is the first to report NPAS3 expression in TNBC patients, highlighting its potential clinical significance.