Risk Factors for Acute Acquired Comitant Esotropia in Children and Young Adults: A Systematic Review

Manjushri Yuan Rou Lee1, Mei Shi Pearl Lee1

  • 1Orthoptics Department, Singapore National Eye Centre, Singapore.

Insights

Acute acquired comitant esotropia (AACE) risk factors are diverse, including benign conditions and serious neurological issues. Further research is needed to clarify causes and improve AACE management.

Area of Science:

  • Ophthalmology
  • Neurology

Background:

  • Acute acquired comitant esotropia (AACE) is a rare condition occurring post-infancy.
  • Its pathogenesis is unclear, with potential links to both benign and severe neurological conditions.
  • Current diagnostic and management guidelines for AACE are not well-defined.

Purpose of the Study:

  • To systematically review and summarize reported risk factors for AACE.
  • To provide insights into the etiology of this rare ophthalmic condition.

Main Methods:

  • A systematic review of studies from CINAHL, MEDLINE, Cochrane Library, and PubMed.
  • Inclusion of studies on risk factors and clinical features of AACE in children and young adults.
  • Critical appraisal and narrative synthesis of extracted data.

Main Results:

  • Twelve studies were included in the review.
  • Six studies reported benign risk factors, while eight identified non-benign factors.
  • Non-benign risk factors included intracranial pathologies, multiple sclerosis, and head trauma.

Conclusions:

  • Study findings have limited generalizability, preventing definitive conclusions on risk factor significance.
  • Further prospective research is necessary to establish cause-effect relationships.
  • Refining diagnostic criteria and management guidelines for AACE requires more objective data and larger studies.
Abstract

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