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Updated: Jun 13, 2025
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Collision tumor comprised of chronic lymphocytic leukemia and myxopapillary ependymoma
Ahmed Aly1, Santhosh Nagaraju2, Rupert Price1
1Department of Neurosurgery, University Hospitals North Midlands NHS Trust, Stoke-on-Trent, United Kingdom.
Background:
Collision tumors involving the co-occurrence of two morphologically and genomically distinct neoplasms in the same anatomical site are exceptionally rare in the central nervous system (CNS).
Case Description:
We report a unique case of a CNS collision tumor comprising chronic lymphocytic leukemia and myxopapillary ependymoma in a 77-year-old male with acute neurological decline. Presumed to represent leukemic infiltration, urgent laminectomy was pursued for tissue diagnosis and spinal cord decompression, revealing the unexpected ependymal component.
Conclusion:
This case highlights the diagnostic and therapeutic challenges inherent to managing collision CNS tumors, particularly when one neoplasm is hematological.
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