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Cerebrospinal fluid protein concentration in patients with lumbar spinal stenosis
Hitoshi Yamahata1, Kosei Ijiri2, Fumito Tanabe2
1Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kirishima, Kagoshima, Japan.
Background:
In this study, we examined the impact and degree of lumbar stenosis on cerebrospinal fluid (CSF) protein concentration.
Methods:
In this retrospective study, we analyzed protein concentrations in CSF samples of 61 patients with lumbar spinal stenosis (LSS) obtained during pre-operative myelography. Patients were divided into two groups: those showing no block to contrast (Group A) versus those showing medium block to contrast below the lumbar puncture level (Group B).
Results:
The CSF protein concentration in Group B (104.3 ± 59 g/dL) patients with medium block was significantly greater than that in Group A (65.1 ± 33 g/dL) patients without medium block.
Conclusion:
A higher average CSF protein concentration was seen in Group B patients with significant lumbar stenosis versus Group A patients without significant lumbar stenosis. Theoretically, damage to the cauda equina in patients with LSS may cause these elevated CSF protein levels.
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