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Updated: Jun 13, 2025

Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Massive Gastrointestinal Bleeding Related to NSAID Use in a Patient with Ileorectal Anastomosis
Esere Nesiama1, Letisha Mirembe2, Kierra Weber3
1University of South Carolina School of Medicine/Prisma Health Department of Orthopaedic Surgery, Columbia, USA.
Abstract:
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to reduce pain and inflammation in over 30 million individuals daily. Gastrointestinal bleeding (GIB) associated with NSAID consumption has been well documented in gastric and duodenal bleeding; however, NSAID-associated GIB distal to the duodenum lacks extensive documentation. This report highlights small bowel occult bleeding related to NSAID use in a patient with a surgical history of robotic total colectomy with ileorectal anastomosis completed 1 year prior. In the case of bright red blood per rectum with associated NSAID use, we recommend NSAID cessation followed by an individualized treatment plan, such as upper/lower endoscopy and/or angioembolization.
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