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Corrigendum: Genetic investigation of Nordic patients with complement-mediated kidney diseases

Viktor Rydberg1, Sigridur Sunna Aradottir1, Ann-Charlotte Kristoffersson1

  • 1Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.

Frontiers in Immunology
|September 9, 2024
PubMed

Keywords:
C3 glomerulopathyatypical hemolytic uremic syndromecomplementgenesmembranoproliferative glomerulonephritis

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Complementation Tests00:49

Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
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