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Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
398

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Related Experiment Video

Updated: Jun 13, 2025

Author Spotlight: Development and Characterization of a Mouse Model for Abdominal Aortic Aneurysm
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Aortic aneurysm: pathophysiology and therapeutic options.

Guang Yang1,2,3,4, Abbas Khan5, Wei Liang1,4

  • 1Division of Renal Medicine Peking University Shenzhen Hospital Shenzhen China.

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|September 9, 2024
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Summary

Aortic aneurysms are deadly, but the ACE2/Ang-(1-7)/MasR pathway shows promise for treatment. This review explores its potential to combat aortic disease and improve patient outcomes.

Keywords:
aortic aneurysmaortic lesioninflammationoxidative stressrenin–angiotensin system

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Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Vascular Biology

Background:

  • Aortic aneurysm (AA) is a significant cause of mortality with limited treatment options beyond surgery.
  • The renin-angiotensin system (RAS) critically regulates vascular health.
  • The ACE2/Ang-(1-7)/MasR axis counteracts detrimental RAS activation, offering a potential therapeutic target for AA.

Purpose of the Study:

  • To review the epidemiology, diagnosis, and treatment of aortic aneurysms, focusing on abdominal aortic aneurysms (AAA).
  • To elucidate the role of the RAS in AAA development and the protective mechanisms of the Ang-(1-7)/MasR pathway.
  • To evaluate the clinical potential of targeting the Ang-(1-7)/MasR pathway for AA prevention and treatment.

Main Methods:

  • Comprehensive literature review on aortic aneurysm epidemiology and RAS.
  • Focus on AAA to detail the role of RAS and the Ang-(1-7)/MasR axis.
  • Analysis of current and potential therapeutic strategies involving agonists and antagonists of the Ang-(1-7)/MasR pathway.

Main Results:

  • The ACE/Ang II/AT1R axis promotes vascular dysfunction and aneurysm development.
  • The ACE2/Ang-(1-7)/MasR axis demonstrates protective effects against AA.
  • Clinical validation of Ang-(1-7)/MasR pathway targeting agents is currently lacking.

Conclusions:

  • The Ang-(1-7)/MasR pathway represents a promising therapeutic target for aortic aneurysms.
  • Further research and clinical validation are needed to develop effective treatments targeting this pathway.
  • Optimizing drug delivery and addressing clinical risks are crucial for therapeutic success.