Uric Acid Status in Subclinical Hypothyroidism

Overt hypothyroidism is associated with high levels of serum uric acid (UA) however, the association between UA and thyroid function in patients with subclinical thyroid dysfunction remains unclear. Subclinical hypothyroidism (SCH) is a common endocrine disorder characterized by normal thyroxine (T4) and triiodothyronine (T3), and elevated thyroid stimulating hormone (TSH) levels, usually without clinical manifestations. Therefore, we carried out a study of patients with subclinical thyroid dysfunction to assess the relationship between thyroid function and UA. This lead us to review the literature to find to what extent subclinical hypothyroidism is associated with uric acid. This study adopts the method of retrospective analysis to collect general information and laboratory results aimed at assessing the correlation between uric acid and thyroid hormone levels. We searched 3 databases using different keywords. Literature search was done for articles published in the last ten years, between 2013-2023. All relevant studies were screened. A total of eighteen articles were finalized for the review. Some studies supported T3 supplementation resulting in SCH correction. Our study indicates that it is important to screen for serum uric acid levels routinely in patients with subclinical hypothyroidism.