Paper integrated microfluidic contact lens for colorimetric glucose detection
Pelin Kubra Isgor1, Taher Abbasiasl1, Ritu Das2
1Department of Biomedical Sciences and Engineering, Koç University Rumelifeneri Yolu Sarıyer Istanbul 34450 Turkey lbeker@ku.edu.tr.
Sensors & Diagnostics
|September 9, 2024
Summary
This study presents a new flexible contact lens with integrated paper-based microfluidics for rapid glucose detection. This innovative device can accurately measure glucose levels in diabetic patients using only a small sample volume.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Ophthalmology
Background:
- Contact lenses offer non-invasive, real-time in situ biomarker analysis.
- Existing electrochemical sensor-integrated contact lenses face challenges with rigidity, eye irritation, and biomarker deviation.
Purpose of the Study:
- To develop a flexible, microfluidic-integrated paper-based contact lens for colorimetric glucose analysis.
- To overcome limitations of rigid electronic components in current contact lens sensors.
Main Methods:
- Fabrication of a flexible, paper-based microfluidic contact lens using a 3D printer.
- Utilizing capillary force for sample routing to detection chambers within microchannels.
- Colorimetric detection of glucose concentration.
Main Results:
- The paper-embedded microfluidic contact lens successfully detected glucose down to 2 mM within approximately 10 seconds.
- The microfluidic system enabled detection of glucose levels from as little as 5 μl of sample.
- The fabricated contact lens accurately detected glucose levels in samples from diabetic patients.
Conclusions:
- The developed contact lens provides a rapid and sensitive method for glucose concentration analysis.
- This approach demonstrates significant potential for non-invasive glucose monitoring in diabetic individuals.
- 3D printing facilitates a simple, batch-compatible fabrication process, eliminating cleanroom requirements.
