Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.3K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.3K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.6K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Hormonal Regulation01:33

Hormonal Regulation

33.0K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.0K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive frailty and adverse outcomes in older people with maintenance hemodialysis: a multicenter prospective cohort study.

BMC geriatrics·2026
Same author

Relationship between the levels of metabolites of organophosphate flame retardants in adult urine and NAFLD.

Journal of environmental health science & engineering·2026
Same author

Electronic pump regulates Fe-Co catalytic center to enhance advanced oxidation performance.

Chemical communications (Cambridge, England)·2026
Same author

Network-guided symptom targets in maintenance hemodialysis using in silico interventions: a multicenter cross-sectional study.

BMC nephrology·2026
Same author

A machine learning-based classification model for interstitial lung disease in rheumatoid arthritis.

Frontiers in medicine·2026
Same author

Innovative nomogram integrating bile acid metabolomics for early diagnosis of intrahepatic cholestasis of pregnancy.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Explaining blood pressure reduction heterogeneity in sodium-glucose cotransporter-2 inhibitor trials: a meta-analysis stratified by patient characteristics.

Journal of hypertension·2026
Same journal

Erratum: Feasibility of the extended, 48-h ambulatory blood pressure monitoring in hemodialysis patients: a multicenter study.

Journal of hypertension·2026
Same journal

Erratum: Neurofibromatosis 2 alleviates ferroptosis and fibrosis in the aortas of spontaneously hypertensive rats through the Yes-associated protein pathway.

Journal of hypertension·2026
Same journal

Reply to comment: Limited public understanding of the risk factors and complications of hypertension.

Journal of hypertension·2026
Same journal

What magnesium depletion score can tell us about arterial stiffness.

Journal of hypertension·2026
Same journal

Nephron deficit as susceptibility, not determinism.

Journal of hypertension·2026
See all related articles

Related Experiment Video

Updated: Jun 13, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

784

Thyroid function and preeclampsia: a two-sample bidirectional Mendelian randomization study.

Chu Li1,2, Jingjing Sheng3, Yawei Zhang1,2

  • 1Center for Reproductive Medicine, Department of Obstetrics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College).

Journal of Hypertension
|September 9, 2024
PubMed
Summary
This summary is machine-generated.

Thyroid dysfunction, including hyperthyroidism and hypothyroidism, causally increases preeclampsia risk. Preeclampsia, however, does not appear to cause thyroid dysfunction, according to this genetic study.

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.6K
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.2K

Related Experiment Videos

Last Updated: Jun 13, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

784
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.6K
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.2K

Area of Science:

  • Endocrinology and Reproductive Health
  • Genetic Epidemiology

Background:

  • Conflicting observational data link thyroid dysfunction and preeclampsia (PE).
  • Causal relationships and directionality between thyroid function and PE remain unclear.

Purpose of the Study:

  • To investigate the causal association between genetically predicted thyroid function and preeclampsia.
  • To determine the causal direction between thyroid dysfunction and PE using bidirectional Mendelian randomization.

Main Methods:

  • Two-sample bidirectional Mendelian randomization (MR) study.
  • Utilized genome-wide association studies (GWAS) summary data from European cohorts.
  • Employed inverse variance weighted (IVW) analysis with MR-Egger and weighted median for sensitivity.

Main Results:

  • Genetically predicted hyperthyroidism and hypothyroidism are causally associated with an increased risk of preeclampsia.
  • Reverse Mendelian randomization showed no significant causal association between preeclampsia and thyroid dysfunction markers (TSH, FT4, FT3, etc.).

Conclusions:

  • Hyperthyroidism and hypothyroidism causally contribute to the development of preeclampsia.
  • Preeclampsia is not causally linked to thyroid dysfunction, suggesting thyroid health is a critical factor in PE prevention.