Ni@TiO₂ nanoribbon array electrode for high-efficiency non-enzymatic glucose biosensing.

Area of Science:

• Electrochemistry
• Materials Science
• Nanotechnology

Background:

• Noble metal-free nanoarrays are crucial for developing advanced catalytic electrodes.
• Efficient glucose biosensing is vital for diagnostics and monitoring.
• Non-enzymatic glucose detection offers advantages over enzyme-based methods.

Purpose of the Study:

• To develop a novel, high-performance, noble metal-free electrode for non-enzymatic glucose biosensing.
• To investigate the electrochemical properties of nickel nanoparticle-decorated titanium dioxide nanoribbon arrays.
• To evaluate the electrode's performance in complex biological samples.

Main Methods:

• Fabrication of nickel nanoparticle-decorated TiO2 nanoribbon arrays on a titanium plate (Ni@TiO2/TP).
• Electrochemical characterization using cyclic voltammetry and amperometry.
• Performance evaluation including sensitivity, detection limit, and selectivity.
• Testing in real human blood serum and cell culture fluid.

Main Results:

• The Ni@TiO2/TP electrode exhibited a rapid response and wide linear range (1 μM to 1 mM) for glucose.
• Achieved a low detection limit of 0.08 μM (S/N = 3) and high sensitivity (10,060 and 3940 μA mM−1 cm−2).
• Demonstrated excellent mechanical flexibility, stability, and efficient performance in biological samples.

Conclusions:

• The Ni@TiO2/TP electrode represents a promising noble metal-free alternative for non-enzymatic glucose biosensing.
• The developed electrode shows high potential for practical applications in clinical diagnostics and biological monitoring.
• The nanoarray architecture enhances catalytic activity and electrode stability.