Photocatalytic synthesis of polyfluoroalkylated dihydropyrazoles and tetrahydropyridazines
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Updated: Jun 13, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Lingli Liu1, Chengli Xiang1, Changduo Pan1,2
1School of Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China. yujintao@cczu.edu.cn.
Abstract:
A photocatalytic trifluoromethylation/cyclization reaction of N-allyl and N-homoallyl aldehyde hydrazones with trifluoromethyl thianthrenium triflate was developed for the synthesis of trifluoromethylated dihydropyrazoles and tetrahydropyridazines. Besides, PhI(O2CCHF2)2 was employed to realize the construction of difluoromethylated dihydropyrazoles and tetrahydropyridazines. These protocols exhibit a broad substrate scope and good functional group tolerance.
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