Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spatial distribution of hyperpolarized [1-<sup>13</sup>C]pyruvate MRI and metabolic PET in the human brain.

Imaging neuroscience (Cambridge, Mass.)·2025

Same author

Hyperpolarized <sup>13</sup>C lactate-to-bicarbonate signal ratio predicts brain metastases response to stereotactic radiosurgery.

Neuro-oncology advances·2025

Same author

Consensus recommendations for hyperpolarized [1-<sup>13</sup>C]pyruvate MRI multi-center human studies.

Magnetic resonance in medicine·2025

Same author

Task activation results in regional <sup>13</sup>C-lactate signal increase in the human brain.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2025

Same author

Probing the energy barriers and stages of membrane protein unfolding using solid-state NMR spectroscopy.

Science advances·2024

Same author

Current methods for hyperpolarized [1-<sup>13</sup>C]pyruvate MRI human studies.

Magnetic resonance in medicine·2024

Same journal

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

Magnetic resonance in medicine·2026

Same journal

Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.

Magnetic resonance in medicine·2026

Same journal

Triple-Pulse <sup>23</sup>Na MRI Sequence (TriNa) for Simultaneous Acquisition of Spin-Density-Weighted and Fluid-Attenuated Images.

Magnetic resonance in medicine·2026

Same journal

Evaluation of Phantom Doping Materials in Quantitative Susceptibility Mapping.

Magnetic resonance in medicine·2026

Same journal

Design of an 8-Channel Transmit 32-Channel Receive 11.7T Head Coil and Evaluation of SNR Gains.

Magnetic resonance in medicine·2026

Same journal

The Potential for Absolute Temperature Imaging Based on Brain Metabolites Using an FID-Shifting Approach in Gradient Echo Planar Spectroscopic Imaging (GREPSI).

Magnetic resonance in medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 13, 2025

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

Particle-based MR modeling with diffusion, microstructure, and enzymatic reactions.

Dylan Archer Dingwell^1,2, Charles H Cunningham^1,2

¹Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Magnetic Resonance in Medicine

|September 9, 2024

Summary

This summary is machine-generated.

A new particle-based in silico model accurately simulates magnetic resonance (MR) signal mechanisms, including metabolic reactions and diffusion. This tool aids in understanding complex dynamics, particularly for hyperpolarized 13C MRI.

Keywords:

carbon‐13 imaging computational modeling hyperpolarized MR

More Related Videos

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

Related Experiment Videos

Last Updated: Jun 13, 2025

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

Area of Science:

Computational modeling
Magnetic Resonance Imaging (MRI)
Biophysics

Background:

Spatial organization of particles significantly impacts MR signal mechanisms.
Understanding these effects is crucial for advanced MRI techniques like hyperpolarized 13C MRI.

Purpose of the Study:

Develop a novel particle-based in silico MR model.
Apply the model to investigate signal mechanisms influenced by particle organization.
Focus on metabolic reaction kinetics, diffusion, and RF refocusing effects.

Main Methods:

Integrated Bloch equations with Brownian dynamics simulation.
Designed simulations for MR signal dynamics, emphasizing hyperpolarized 13C MRI.
Validated model with phantom scans and spectrophotometric assays.

Main Results:

Accurately reproduced enzyme-mediated pyruvate-to-lactate conversion kinetics.
Replicated nonlinear changes in reaction rates with varying structural restrictions.
Characterized diffusion-weighted contributions in gradient-echo sequences.

Conclusions:

The developed in silico model accurately reproduces diverse MR signal mechanisms.
Establishes the model's utility for investigating multifactorial signal dynamics.
Provides a powerful tool for analyzing hyperpolarized 13C MRI data.