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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Longitudinal Research02:20

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Evidence-based, patient-centred management of tooth wear: 15-years insights from the Radboud Tooth Wear Project.

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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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[Time wears on everyone, but not equally quickly].

H Bronkhorst, E M Bronkhorst, S I Kalaykova

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    Summary
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    Tooth wear progression varies greatly between individuals and even on different tooth surfaces. This highlights the need for personalized treatment plans based on precise tooth wear measurements.

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    Area of Science:

    • Dentistry
    • Dental Biomaterials
    • Oral Health

    Background:

    • Tooth wear is a common dental issue with varying progression rates.
    • Accurate measurement of tooth wear is crucial for effective treatment planning.
    • Previous studies have not fully captured the localized and individual nature of tooth wear progression.

    Purpose of the Study:

    • To quantify tooth wear progression over three years using serial intra-oral scans.
    • To analyze the variability of tooth wear progression across different patients, teeth, and surfaces.
    • To emphasize the importance of individualized assessment for restorative treatment decisions.

    Main Methods:

    • 30 patients underwent intra-oral scanning at baseline and after 3 years.
    • GeoMagic software was used to precisely superimpose scans for comparison.
    • Maximum height difference was measured on 64 tooth surfaces per patient.

    Main Results:

    • Significant variation in tooth wear progression was observed among patients.
    • Tooth wear rates differed substantially between individual teeth within the same mouth.
    • Highly localized differences in wear were noted even on surfaces of a single tooth.

    Conclusions:

    • Tooth wear progression is a highly individualized and localized phenomenon.
    • Standardized treatment approaches for tooth wear may be insufficient.
    • Accurate, individualized tooth wear measurement is essential for guiding restorative treatment.