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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
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Atopic Dermatitis (Eczema) Guidelines 2023: Highlights.

Anna De Benedetto1, Mark Boguniewicz2, Peck Y Ong3

  • 1Department of Dermatology, University of Rochester Medical Center, Rochester, NY.

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|September 9, 2024
PubMed
Summary

Updated guidelines for atopic dermatitis (AD) offer evidence-based recommendations for managing this chronic inflammatory skin condition. The guidelines emphasize integrating patient values and preferences for personalized treatment plans.

Keywords:
Allergy immunotherapyAtopic dermatitisElimination dietGuidelinesManagementSystemic treatmentTopical

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Area of Science:

  • Dermatology
  • Allergy and Immunology
  • Evidence-Based Medicine

Background:

  • Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disorder impacting quality of life.
  • Its complex pathogenesis involves eczematous lesions, pruritus, and recurrent infections.

Purpose of the Study:

  • To provide an overview of the recently updated American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma and Immunology Joint Task Force Atopic Dermatitis Guideline.
  • To discuss how these recommendations can be applied in clinical practice.

Main Methods:

  • A multidisciplinary panel utilized systematic reviews and meta-analyses.
  • Guideline development followed trustworthy standards, including conflict of interest mitigation and GRADE methodology.

Main Results:

  • The guideline offers recommendations on topical treatments, dilute bleach baths, dietary changes, allergen immunotherapy, and systemic therapies.
  • Emphasis is placed on evidence-based medicine, integrating patient values and preferences.

Conclusions:

  • The updated guidelines provide a framework for clinicians to select optimal treatment plans for atopic dermatitis.
  • Integrating patient values and preferences is crucial for effective management of AD.