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New insight into primary hyperparathyroidism using untargeted metabolomics.

Marta Wielogórska-Partyka1, Joanna Godzien2, Beata Podgórska-Golubiewska1

  • 1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276, Białystok, Poland.

Scientific Reports
|September 9, 2024
PubMed
Summary

Primary Hyperparathyroidism (PHPT) involves excess parathormone (PTH) and calcium imbalance. Metabolomics reveals distinct metabolic profiles in PHPT patients, linking specific metabolites to complications like cardiovascular issues and reduced bone density.

Keywords:
Bone mineral densityCalciumPrimary hyperparathyroidismUntargeted metabolomics

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Area of Science:

  • Endocrinology and Metabolism
  • Biochemistry
  • Medical Diagnostics

Background:

  • Primary Hyperparathyroidism (PHPT) is a disorder of excessive parathormone (PTH) secretion, leading to calcium homeostasis disruption.
  • Untargeted metabolomics is a powerful tool for uncovering complex metabolic alterations in various diseases, including PHPT.

Purpose of the Study:

  • To investigate and identify distinct plasma metabolic profiles in patients with PHPT compared to healthy controls.
  • To explore the association of specific metabolites with clinical manifestations and complications of PHPT.

Main Methods:

  • Retrospective, single-center study involving 28 female PHPT patients and 30 healthy female controls.
  • Application of untargeted plasma metabolomics using two complementary liquid-phase separation techniques.
  • Analysis of plasma metabolites to identify differences between PHPT patients and controls.

Main Results:

  • Distinct metabolic patterns were identified, differentiating PHPT patients from healthy controls.
  • Specific metabolic imbalances were linked to potential complications: L-amino acids with peptic ulcer disease, gamma-glutamyls with oxidative stress, and ADMA with cardiovascular disease.
  • Several metabolites, including gamma-glutamyls, caffeine, sex hormones, carnitine, S-1-P, and steroids, were associated with reduced bone mineral density (BMD).

Conclusions:

  • Metabolomic profiling provides valuable insights into the pathophysiology of PHPT.
  • These findings highlight potential biomarkers and metabolic pathways involved in PHPT and its associated complications.