MiRNA-132/212 encapsulated by adipose tissue-derived exosomes worsen atherosclerosis progression
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View abstract on PubMed
Summary
This summary is machine-generated.Adipose tissue exosomes worsen atherosclerosis by promoting cell death and growth in blood vessels. MicroRNA-132/212 within these exosomes drives this process, offering potential targets for treatment.
Area Of Science
- Cardiovascular Biology
- Exosome Biology
- Molecular Medicine
Background
- Visceral adipose tissue in obesity is a cardiovascular risk factor.
- The role of adipose tissue exosomes in atherosclerosis is unclear.
Purpose Of The Study
- To investigate the impact of adipose tissue-derived exosomes on atherosclerosis progression.
- To elucidate the underlying mechanisms involving microRNA-132/212.
Main Methods
- Isolation of exosomes from diet-induced obesity mouse adipose tissue.
- In vivo and in vitro evaluation of exosome effects on endothelial cells and vascular smooth muscle cells (VSMCs).
- Analysis of microRNA cargo and target genes.
Main Results
- Adipose tissue-derived exosomes (AT-EX) accelerate atherosclerosis by increasing endothelial apoptosis and VSMC proliferation/migration.
- MicroRNA-132/212 (miR-132/212) within AT-EX targets specific genes to promote these effects.
- Melatonin reduces exosomal miR-132/212, mitigating AT-EX pro-atherosclerotic impact.
Conclusions
- AT-EX play a pathological role in atherosclerosis progression.
- miR-132/212 is a key mediator in AT-EX-induced atherosclerosis.
- miR-132/212 presents potential diagnostic and therapeutic targets for atherosclerosis.
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