Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structure and Function of Platelets

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Identification of the mitochondria-related gene <i>IRF7</i> shared by physical exercise and Parkinson's disease and exploration of its potential molecular mechanisms.

PeerJ·2026

Same author

The relationship between medical students' attitudes toward artificial intelligence and their personality traits: a multicenter study in China.

Frontiers in public health·2026

Same author

Strategy of adult thalamic glioma surgery: Thoughts and practices based on thalamic glioma classification.

Neurosurgical review·2026

Same author

Chemotherapy induces multiple sclerosis-like neuropathologies that can be rescued by clobetasol.

Cell death and differentiation·2025

Same author

Integrated Pan-Cancer Analysis and Experimental Verification of the Roles of Retinoid-Binding Proteins in Breast Cancer.

Cancers·2025

Same author

T-cell immunoglobulin and mucin domain-containing protein 3-mediated immunomodulation in myeloid cells and keratinocytes in the development of severe acne.

Molecular biomedicine·2025

Search research articles

Related Experiment Video

Updated: Jun 13, 2025

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Research progress on platelets in glioma.

Mingrong Zuo^1,2, Tengfei Li^1,2, Zhihao Wang²

¹Department of Pediatric Neurosurgery, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Chinese Medical Journal

|September 10, 2024

Summary

This summary is machine-generated.

Platelets, or tumor-educated platelets (TEPs), promote glioma growth and resistance. Targeting these platelets offers new therapeutic strategies for glioblastoma, the deadliest brain tumor.

More Related Videos

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Published on: January 10, 2025

A Human Glioblastoma Organotypic Slice Culture Model for Study of Tumor Cell Migration and Patient-specific Effects of Anti-Invasive Drugs

A Human Glioblastoma Organotypic Slice Culture Model for Study of Tumor Cell Migration and Patient-specific Effects of Anti-Invasive Drugs

Published on: July 20, 2017

Related Experiment Videos

Last Updated: Jun 13, 2025

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Published on: January 10, 2025

A Human Glioblastoma Organotypic Slice Culture Model for Study of Tumor Cell Migration and Patient-specific Effects of Anti-Invasive Drugs

A Human Glioblastoma Organotypic Slice Culture Model for Study of Tumor Cell Migration and Patient-specific Effects of Anti-Invasive Drugs

Published on: July 20, 2017

Area of Science:

Neuro-oncology
Hematology
Tumor Microenvironment

Background:

Gliomas, particularly glioblastoma, are aggressive brain tumors with poor prognoses.
The tumor microenvironment, including platelets, significantly contributes to glioblastoma's resistance to therapy.
Platelets are increasingly recognized for their role beyond hemostasis, actively participating in cancer progression.

Purpose of the Study:

To review the multifaceted role of platelets in glioma development and progression.
To elucidate the molecular mechanisms underlying the interaction between tumor-educated platelets (TEPs) and glioma cells.
To explore the potential of targeting platelets for novel glioblastoma therapies.

Main Methods:

Literature review of recent research on platelets in glioma.
Analysis of molecular mechanisms of TEP-glioma cell interactions.
Discussion of therapeutic strategies targeting platelets in glioblastoma.

Main Results:

Glioma cells educate platelets into TEPs, which enhance glioma proliferation, invasion, stemness, and chemoresistance.
TEPs can serve as a source of genetic information for glioma diagnosis and treatment monitoring.
Platelet membranes show promise as biomimetic drug delivery systems for anti-glioma therapies.

Conclusions:

Platelets are critical components of the glioma tumor microenvironment, promoting malignancy.
Targeting TEPs and their interactions presents a promising avenue for glioblastoma treatment.
Further research into platelet-mediated mechanisms can lead to innovative diagnostic and therapeutic approaches for glioma.