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Updated: May 8, 2026

Method of Studying Palatal Fusion using Static Organ Culture
Published on: September 19, 2015
Maximum mouth opening in patients with cleft lip and palate or craniofacial anomalies compared with non-affected
Richard Campbell1,2, Brigitte Trego1,2, Elizabeth S Gosnell1,2
1College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Background:
There are limited published data on maximum mouth opening (MMO) for children with cleft lip or palate (CLP) or craniofacial anomalies (CFA).
Aim:
To report MMO of patients with CLP or CFA compared with non-affected controls.
Design:
Retrospective cross-sectional review of electronic medical and dental records. Patients with CLP or CFA with recorded MMO, height, and weight were included and compared with a non-affected control individuals seen during orthodontic screening. Outcome measures included MMO, recorded in millimeters of inter-incisal distance, age, height, weight, and sex.
Results:
Patients with CLP or CFA (n = 376) were matched by age and body mass standardized index (BMIz) to the non-affected pool (n = 376). The affected group had a MMO of 43.14 mm (±7.1 mm) compared with the control group MMO of 48.01 mm (±7.6 mm) with a statistically significant difference of -4.86 mm (p < .0001). Specifically, MMO of the unilateral cleft group is 4.26 mm smaller than that of non-affected controls (p < .0001). MMO of the bilateral cleft group is 3.65 mm smaller than that of non-affected controls (p = 0.0063).
Conclusions:
MMO for patients with CLP was significantly smaller as compared to non-affected controls. This study helps establish MMO values for children with CLP and CFA.

