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Intersecting evidence: Bibliometric analysis and clinical trials illuminate immunotherapy in KRAS-mutation cancer: A

Hongyang Liu1, Min Qiang1, Ying Zhang2

  • 1The First Hospital of Jilin University, Chang Chun, China.

Medicine
|September 10, 2024
PubMed

Insights

This study identifies emerging immunotherapies for KRAS-mutant cancers, highlighting immune checkpoint blockades (ICBs) as effective treatments. Combination therapies and T-cell therapies show promise for personalized cancer treatment strategies.

Area of Science:

  • Oncology
  • Immunotherapy
  • Cancer Genetics

Background:

  • KRAS mutations are key drivers in cancers like lung and pancreatic cancer.
  • Targeted therapies for KRAS-mutant tumors face management challenges.
  • Emerging immunotherapies offer new treatment avenues.

Purpose of the Study:

  • Identify and analyze emerging immunotherapies for KRAS-mutant cancers.
  • Evaluate the effectiveness of current and novel treatments.
  • Highlight key research areas for advancing personalized cancer therapy.

Main Methods:

  • Bibliometric analysis of publications (Jan 2008-Mar 2023) using Web of Science and Citespace.
  • Comprehensive review of 52 clinical trials from ClinicalTrials.gov and WHO registry.
  • Focus on immune checkpoint blockades (ICBs) and novel therapeutic strategies.

Main Results:

  • Increased research focus on tumor immune microenvironment and precision therapy.
  • Immune checkpoint blockades (ICBs) demonstrate effectiveness, especially in combination therapies.
  • T-cell receptor T-cell therapy and vaccines show promising potential for KRAS-mutant cancers.

Conclusions:

  • KRAS-mutant cancer treatment benefits from a focus on the tumor microenvironment and gene co-mutations.
  • Multidisciplinary approaches integrating genetic, immunological, and computational studies are crucial.
  • Personalized treatment strategies and novel therapeutic targets are advancing KRAS-mutant cancer care.

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