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Bifidobacterium longum subsp. infantis YLGB-1496-Toxicological evaluation
Jian Zhao1, Yueyi Guo1, Qiuyue Jiang2
1Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, China.
Journal of Applied Toxicology : JAT
|September 10, 2024
Summary
Bifidobacterium infantis YLGB-1496, a potential probiotic, demonstrated safety in genotoxicity and rat toxicity studies. These findings support its use in infant formula.
Area of Science:
- Microbiology
- Toxicology
- Probiotic research
Background:
- Bifidobacterium infantis YLGB-1496 is a bacterial strain isolated from human breast milk.
- Extensive research is needed to assess the safety of potential probiotic strains.
Purpose of the Study:
- To evaluate the safety of Bifidobacterium infantis YLGB-1496 for use as a probiotic.
- To conduct genotoxicity assays and a 13-week oral rat toxicity study.
Main Methods:
- Ames test, in vivo mouse micronucleus assay, and in vivo mouse spermatocyte chromosome aberration assay were performed.
- Sprague-Dawley rats were administered B. infantis YLGB-1496 orally at doses up to 1.5 g/kg bw/day for 13 weeks.
Main Results:
- B. infantis YLGB-1496 showed no genotoxic activity in any assay.
- No treatment-related adverse effects were observed in rats during the 13-week toxicity study.
- No concerns regarding translocation or pathogenicity were identified.
Conclusions:
- The safety assessments indicate no adverse effects associated with B. infantis YLGB-1496.
- Results support the potential use of B. infantis YLGB-1496 as a probiotic in infant formula.
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