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Bifidobacterium longum subsp. infantis YLGB-1496-Toxicological evaluation

Jian Zhao1, Yueyi Guo1, Qiuyue Jiang2

  • 1Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, China.

Journal of Applied Toxicology : JAT
|September 10, 2024
PubMed

Insights

Bifidobacterium infantis YLGB-1496, a potential probiotic, demonstrated safety in genotoxicity and rat toxicity studies. These findings support its use in infant formula.

Area of Science:

  • Microbiology
  • Toxicology
  • Probiotic research

Background:

  • Bifidobacterium infantis YLGB-1496 is a bacterial strain isolated from human breast milk.
  • Extensive research is needed to assess the safety of potential probiotic strains.

Purpose of the Study:

  • To evaluate the safety of Bifidobacterium infantis YLGB-1496 for use as a probiotic.
  • To conduct genotoxicity assays and a 13-week oral rat toxicity study.

Main Methods:

  • Ames test, in vivo mouse micronucleus assay, and in vivo mouse spermatocyte chromosome aberration assay were performed.
  • Sprague-Dawley rats were administered B. infantis YLGB-1496 orally at doses up to 1.5 g/kg bw/day for 13 weeks.

Main Results:

  • B. infantis YLGB-1496 showed no genotoxic activity in any assay.
  • No treatment-related adverse effects were observed in rats during the 13-week toxicity study.
  • No concerns regarding translocation or pathogenicity were identified.

Conclusions:

  • The safety assessments indicate no adverse effects associated with B. infantis YLGB-1496.
  • Results support the potential use of B. infantis YLGB-1496 as a probiotic in infant formula.
Keywords:
Bifidobacterium longumgenotoxicityprobioticsafetytoxicology

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