Sensing Interfaces Engineering for Organic Thin Film Transistors-Based Biosensors: Opportunities and Challenges

Area of Science:

• Materials Science
• Biotechnology
• Sensor Technology

Background:

• Organic thin film transistors (OTFTs) are promising for biosensing due to their sensitivity, low cost, and biocompatibility.
• Challenges in OTFT biosensors include probe immobilization issues like adsorption and disordered conformation.
• Recent advancements focus on optimizing sensing interfaces for effective probe attachment.

Purpose of the Study:

• To review efficient immobilization strategies for biological sensing probes on OTFTs developed in the last five years.
• To classify OTFT biosensors based on their sensing interfaces.
• To summarize applications of OTFT biosensors in liquid phase detection.

Main Methods:

• Classification of biosensors by sensing interface.
• Discussion of various biological sensing probes.
• Brief description of three common immobilization methods and their challenges.

Main Results:

• Identified key challenges in biological probe immobilization on OTFTs.
• Highlighted efficient immobilization strategies developed recently.
• Summarized applications in liquid phase detection.

Conclusions:

• Optimizing sensing interface engineering is crucial for high-performance OTFT biosensors.
• Efficient immobilization of biological probes enhances biosensor capabilities.
• This review provides a timely overview for advancing OTFT-based biosensing technology.