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Related Experiment Video

Updated: Jun 13, 2025

Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture
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Digital Clock and Recall: a digital, process-driven evolution of the Mini-Cog.

Joyce Gomes-Osman1,2, Soo Borson3,4, Claudio Toro-Serey1

  • 1Linus Health, Inc., Boston, MA, United States.

Frontiers in Human Neuroscience
|September 10, 2024
PubMed
Summary

The Digital Clock and Recall (DCR) tool shows higher sensitivity in detecting cognitive impairment compared to the original Mini-Cog. This digital adaptation improves the identification of mild cognitive impairment and dementia in older adults.

Keywords:
Digital Clock and RecallMini-Cogcognitive screendementianext-generationprocess-driven

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Area of Science:

  • Neurology
  • Gerontology
  • Medical Diagnostics

Background:

  • Alzheimer's disease and related dementias (ADRD) pose a significant public health challenge.
  • Brief cognitive screening tools are crucial for early ADRD detection but face adoption barriers.
  • The Mini-Cog© is a widely used cognitive screening tool.

Purpose of the Study:

  • To compare the efficacy of the Digital Clock and Recall (DCR) tool against the original Mini-Cog©.
  • To evaluate the DCR's performance in a clinical trial setting for identifying cognitive impairment.
  • To assess the DCR's potential to improve ADRD recognition in healthcare.

Main Methods:

  • Administered DCR and Mini-Cog© to 828 participants in the Bio-Hermes-001 clinical trial.
  • Classified participants as cognitively unimpaired, mild cognitive impairment (MCI), or dementia likely due to AD (DLAD).
  • Analyzed inter-rater reliability and concordance between Mini-Cog© and DCR scoring.

Main Results:

  • DCR demonstrated significantly higher sensitivity in detecting cognitive impairment compared to the Mini-Cog©.
  • The DCR correctly identified more cases of cognitive impairment missed by the Mini-Cog©.
  • Digital metrics from DCR capture clock drawing dynamics, enhancing impairment detection.

Conclusions:

  • The DCR is a more sensitive, automated, and process-driven digital adaptation of the Mini-Cog©.
  • Digital clock drawing analysis offers advantages in diagnosing cognitive impairment.
  • The DCR shows promise for improving the early detection of ADRD in clinical practice.