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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Insulin: Biosynthesis, Chemistry, and Preparation01:25

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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
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An explainable Artificial Intelligence software system for predicting diabetes.

Parvathaneni Naga Srinivasu1,2, Shakeel Ahmed3, Mahmoud Hassaballah4,5

  • 1Department of Teleinformatics Engineering, Federal University of CearĂ¡, Fortaleza, 60455-970, Brazil.

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Summary
This summary is machine-generated.

This study introduces an Explainable Artificial Intelligence (XAI) system for non-invasive diabetes surveillance. The novel system accurately identifies abnormal glucose levels using Bi-LSTM and CNN models, improving patient comfort and monitoring.

Keywords:
Bi-LSTMBlood glucose levelsConvolutional neural networksHyperparametersROC curvesSpectrogram images

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Area of Science:

  • Biomedical Engineering
  • Artificial Intelligence in Healthcare
  • Diabetes Technology

Background:

  • Minimally invasive blood glucose monitoring causes discomfort.
  • Effective diabetes surveillance is crucial for managing medical expenses.
  • Existing methods require blood extraction, posing challenges for continuous monitoring.

Purpose of the Study:

  • To develop an Explainable Artificial Intelligence (XAI) system for non-invasive glucose level analysis.
  • To create an intelligible machine learning model for predicting and explaining glucose level outcomes.
  • To improve diabetes surveillance through a comfortable and accurate monitoring system.

Main Methods:

  • Utilized Bi-directional Long Short-Term Memory (Bi-LSTM) and Convolutional Neural Network (CNN) for abnormal glucose level analysis.
  • Acquired glucose level data via glucose oxidase (GOD) strips placed on the body.
  • Converted signal data to spectrogram images for classification (low, average, abnormal glucose).
  • Trained an individualized monitoring model using labeled spectrogram images and an XAI-driven architecture.

Main Results:

  • The proposed XAI model effectively tracks real-time glucose levels.
  • Performance evaluation using confusion matrix metrics demonstrated high accuracy.
  • The model successfully identified individuals with elevated glucose levels.

Conclusions:

  • The developed XAI system offers a promising non-invasive approach for diabetes surveillance.
  • The integration of Bi-LSTM, CNN, and XAI enhances the intelligibility and accuracy of glucose monitoring.
  • This technology has the potential to significantly improve the management of diabetes and reduce healthcare costs.