The microenvironmental factors induced invasive tumor cells in glioblastoma
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View abstract on PubMed
Summary
This summary is machine-generated.Glioblastoma cells can become invasive due to tumor microenvironment stress, with Oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) expression linked to invasiveness and recurrence. Targeting OSMR may impact glioblastoma progression.
Area Of Science
- Neuro-oncology
- Cancer Biology
- Tumor Microenvironment Research
Background
- Glioblastoma (GBM) cells exhibit plasticity, shifting between proliferative and invasive phenotypes.
- Peritumoral GBM cells possess high invasiveness, contributing to surgical resistance and tumor recurrence.
- Mechanisms by which the tumor microenvironment (TME) regulates GBM invasiveness are not fully understood.
Purpose Of The Study
- To investigate the role of the TME in regulating GBM cell invasiveness.
- To identify molecular markers associated with GBM cell invasiveness.
- To explore the impact of environmental stress on GBM cell behavior.
Main Methods
- Single-cell RNA sequencing to analyze cellular heterogeneity in GBM, microglia, and macrophages.
- In vitro experiments to assess the effect of hypoxic, acidic, and low-glucose conditions on gene expression.
- Functional assays to evaluate the influence of TME stress on GBM cell proliferation, migration, and invasion.
Main Results
- Single-cell RNA sequencing revealed heterogeneity in GBM cells, microglia, and macrophages.
- Expression of Oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) correlated with higher invasiveness in core GBM cells.
- In vitro environmental stress (hypoxia, acidity, low glucose) upregulated OSMR and LIFR expression.
- TME stress significantly impacted GBM cell proliferation, migration, and invasion.
Conclusions
- Tumor microenvironment stress, including hypoxia, acidity, and low glucose, drives GBM cell invasiveness.
- OSMR and LIFR expression are key indicators of GBM cell invasiveness and are modulated by TME conditions.
- Differences in core and peripheral TMEs influence GBM invasive properties, highlighting OSMR's role in tumor progression and therapeutic response.
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