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Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review

Abdulqadir J Nashwan1,2, Mohammad T Abuawwad3, Jaber H Jaradat4

  • 1Nursing & Midwifery Research Department Hamad Medical Corporation Doha Qatar.

Health Science Reports
|September 10, 2024
PubMed

Insights

Iron overload is a concern for chronic kidney disease (CKD) patients on peritoneal dialysis (PD), though less common now. Treatment with iron chelators is effective but requires careful monitoring for side effects.

Area of Science:

  • Nephrology
  • Hematology
  • Internal Medicine

Background:

  • Chronic kidney disease (CKD) patients on peritoneal dialysis (PD) face risks of iron overload.
  • Iron overload can negatively impact patient prognosis and overall health.

Purpose of the Study:

  • To review the prevalence and implications of iron overload in CKD patients undergoing PD.
  • To synthesize current understanding of contributing factors, effects, and treatments for iron overload in this population.

Main Methods:

  • A comprehensive literature search was performed across five databases.
  • 18 selected papers involving 381 PD patients were analyzed.

Main Results:

  • No diagnostic cutoff for iron overload was established.
  • Factors include iron supplements and MRI diagnosis; iron overload hinders growth in young patients.
  • Adverse effects, particularly cardiac issues, were noted; iron chelators like Deferoxamine and Deferasirox showed efficacy.
  • Estimated liver iron overload prevalence in PD patients is 10–28.6%, lower than in hemodialysis (HD) patients (75%).

Conclusions:

  • Iron overload is less prevalent in current PD patients due to improved treatments like erythropoiesis-stimulating agents.
  • Iron chelation therapy is beneficial but carries risks, requiring vigilant monitoring and intervention.
Abstract

Keywords:
chelatingchronic kidney diseaseferritiniron overloadperitoneal dialysis

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