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Functional components of surface membranes: potential targets for pharmacological manipulation
Pharmacological Reviews
|December 1, 1978
Summary
Biochemical studies of cell membranes have yielded a working model of cell membrane architecture. These advances enable new pharmacological strategies for cell manipulation through surface membranes.
Area of Science:
- Biochemistry
- Pharmacology
- Membrane Biology
Background:
- Cell membrane studies have advanced significantly.
- Biochemical approaches are proving effective in understanding cell membranes.
Purpose of the Study:
- To highlight key developments in membrane studies.
- To demonstrate the utility of biochemical approaches for cell membrane research.
- To inform pharmacologists about new avenues for drug development.
Main Methods:
- Survey of three major developments in membrane studies.
- Review of biochemical findings related to cell membrane architecture.
Main Results:
- A functional model of cell membrane architecture is now available.
- Biochemical methods have successfully elucidated membrane structures.
- Significant progress has been made in understanding cell surface membranes.
Conclusions:
- Biochemical approaches have validated current cell membrane models.
- The established model of cell membrane architecture facilitates new drug design.
- Pharmacological manipulation of cells via surface membranes is now more feasible.